AALL03N1: Understanding the Role of Adherence and Ethnic Differences in Survival After Childhood ALL

Acute Myeloid Leukemia

AAML0523: A Phase I/II Study of CLOLAR (Clofarabine IND# 73,789) in Combination with Cytarabine in Pediatric Patients With Refractory/Relapsed Leukemia

AAML0631: Risk Adapted Treatment of Newly Diagnosed Childhood Acute Promyelocytic Leukemia (APL) Using Arsenic Trioxide (Trisenox, IND#103,331) During Consolidation

AAML07P1: A Phase II Pilot Study of Bortezomib (PS-341, Velcade, IND #58,443) Combined with Reinduction Chemotherapy in Children and Young Adults with Recurrent, Refractory or Secondary Acute Myeloid Leukemia

AAML05P1: Killer Immunoglobulin-like Receptor (KIR) Incompatible Unrelated Donor Hematopoietic Cell Transplantation (HCT) for Refractory and Relapsed Acute Myelogenous Leukemia (AML) and Newly Diagnosed AML with Monosomy 7 or -5/5q- in Children

AAML0431: The Treatment of Down Syndrome Children with Acute Myeloid Leukemia (AML) and Myelodysplastic Syndrome (MDS) Under the Age of 4 Years

Adrenocortical Carcinoma

ARAR0332: Treatment of Adrenocortical Tumors with Surgery plus Lymph Node Dissection and Multiagent Chemotherapy

Brain Tumors

ACNS0333: Treatment of Atypical Teratoid/Rhabdoid Tumors of the Central Nervous System With Surgery, Intensive Chemotherapy, and 3-D Conformal Radiation

ACNS0334: A Phase III Randomized Trial for the Treatment of Newly Diagnosed Supratentorial PNET and High Risk Medulloblastoma in Children < 36 Months Old with Intensive Induction Chemotherapy with Methotrexate Followed by Consolidation with Stem Cell Rescue vs. the Same Therapy Without Methotrexate

ACNS0621: Cilengitide (EMD 121974) (IND# 59073) in Recurrent or Progressive and Refractory Childhood High-Grade Glioma

ACNS0332: Efficacy of Carboplatin Administered Concomitantly With Radiation and Isotretinoin as a Pro-Apoptotic Agent in Other Than Average Risk Medulloblastoma/PNET Patients

ACNS0221: A Phase II Study of Conformal Radiotherapy in Patients with Low Grade Gliomas

ACNS02B3: A Children's Oncology Group Protocol for Collecting and Banking Pediatric Brain Tumor Research Specimens 

Registry for Central Nervous System Atypical Teratoid/Rhabdoid Tumor

ACNS0331: A Study Evaluating Limited Target Volume Boost Irradiation and Reduced Dose Craniospinal Radiotherapy 18.00 Gy and Chemotherapy in Children with Newly Diagnosed Standard Risk Medulloblastoma: A Phase III Double Randomized Trial

Headstart III: Dose-intensive Chemotherapy for Children Less Than 10 Years of Age, Newly-diagnosed with Malignant Brain Tumors: A Study of Intensive Induction Chemotherapy Followed by Consolidation with Myeloablative Chemotherapy and Autologous Stem Cell Rescue
 
Ewing Sarcoma

AEWS07B1: A Children's Oncology Group Protocol for Collecting and Banking Ewing Sarcoma Specimens

AEWSO331: European Ewing Tumor Working Initiative of National Groups Ewing Tumor Studies 1999 (EURO-E.W.I.N.G.99)

Germ Cell Tumors

AGCT0521: Treatment of Recurrent or Resistant Pediatric Malignant Germ Cell Tumors with Paclitaxel, Ifosfamide and Carboplatin

AGCT0132: A Phase III Study of Reduced Therapy in the Treatment of Children with Low and Intermediate Risk Extracranial Germ Cell Tumors

Hepatoblastoma

AHEP0731: Treatment of Children With All Stages of Hepatoblastoma

Hodgkin's Lymphoma

AHOD0831: A Non-Randomized Phase III Study of Response Adapted Therapy for the Treatment of Children With Newly Diagnosed High Risk Hodgkin Lymphoma

AHOD04B1: Hodgkin's Disease Banking Study

AHOD3P1: Treatment of Children with Newly-Diagnosed Low Stage Lymphocyte Predominant Hodgkin Disease (LPHD)

ALTE04N1: Health-Related Outcomes for Hodgkin's Disease Survivors

Melanoma

E1697: Phase III Randomized Study of Four Weeks High Dose INF Alpha-2b in Stage T2bN0, T3a-b, T4a-bN0, and T1-4, N1a, 2a, 3 (Microscopic) Melanoma - An ECOG Coordinated Intergroup Trial

Nasopharyngeal Carcinoma

ARAR0331: Treatment of Childhood Nasopharyngeal Carcinoma with Neoadjuvant Chemotherapy and Concomitant Chemoradiotherapy

Neuroblastoma

ANBL0532: Phase III Randomized Trial of Single vs. Tandem Myeloablative as Consolidation Therapy for High-Risk Neuroblastoma

ANBL0531: Response- and Biology-based Therapy for Intermediate-risk Neuroblastoma

ANBL00P3: Use of Intravenous Gammaglobulin Therapy for Patients with Neuroblastoma Associated Opsoclonus-Myoclonus-Ataxia Syndrome Treated with Chemotherapy and Prednisone

ANBL00B1: Neuroblastoma Biology Studies

ANBL0032: Phase III Randomized Study of Chimeric Anti-GD2 in High Risk Neuroblastoma Following Myeloablative Therapy and Autologous Stem Cell Rescue

Non Hodgkin's Lymphoma

ANHL04B1: Rare and Cutaneous Non Hodgkin's Lymphoma Registry 

Osteogenic Sarcoma

AOST06B1: A Children's Oncology Group Protocol for Collecting and Banking Osteosarcoma Specimens

AOST06P1: Feasibility and Dose Discovery Analysis of Zoledronic Acid With Concurrent Chemotherapy in the Treatment of Newly Diagnosed Metastatic Osteosarcoma

Liposomal Muramyl Tripeptide Phosphatidyl Ethanolamine (L-MTP-PE): Compassionate Access for High-risk Osteosarcoma

AOST0331: A Randomized Trial of the European and American Osteosarcoma Study Group to Optimize Treatment Strategies for Resectable Osteosarcoma Based on Histological Response to Pre-Operative Chemotherapy

Renal Tumors

AREN0533: Treatment of Newly Diagnosed Higher Risk Favorable Histology Wilms Tumors

AREN0532: Treatment for Very Low, Low and Standard Risk Favorable Histology Wilms Tumor

AREN03B2: Renal Tumors Classification, Biology, and Banking Study

AREN0321: Treatment of High Risk Renal Tumors

Retinoblastoma

ARET0332: A Study of Unilateral Retinoblastoma With and Without Histopathologic High-Risk Features and the Role of Adjuvant Chemotherapy

Rhabdomyosarcoma / Soft Tissue Sarcoma

ARST0332: Risk-Based Treatment for Pediatric Non-Rhabdomyosarcoma Soft Tissue Sarcomas (NRSTS)

ARST0531: Randomized Study of Vincristine, Dactinomycin and Cyclophosphamide (VAC) Versus VAC Alternating With Vincristine and Irinotecan (VI) for Patients with Intermediate-Risk Rhabdomyosarcoma (RMS)

ARST0331: Vincristine, Dactinomycin, and Lower Doses of Cyclophosphamide With or Without Radiation Therapy for Patients with Newly Diagnosed Low-Risk Embryonal / Botryoid / Spindle Cell Rhabdomyosarcoma

D9902: A Group-wide Protocol For Collecting and Banking Pediatric Cancer Research Specimens - IRSG

Solid Tumors

ADVL0821: A Phase II Study of IMC-A12 (Anti-IGF-I Receptor Monoclonal Antibody, IND# 100947, NSC# 742460) in Children With Relapsed/Refractory Solid Tumors

New Agents (Phase I and Phase II Studies)

ACNS0221: A Phase II Study of Conformal Radiotherapy in Patients with Low Grade Gliomas

ACNS0621: Cilengitide (EMD 121974) (IND# 59073) in Recurrent or Progressive and Refractory Childhood High-Grade Glioma

AGCT0521: Treatment of Recurrent or Resistant Pediatric Malignant Germ Cell Tumors with Paclitaxel, Ifosfamide and Carboplatin

AREN0321: Treatment of High Risk Renal Tumors

ASCT0521: Soluble Tumor Necrosis Factor Receptor: Enbrel (Etanercept) for the Treatment of Acute Non-Infectious Pulmonary Dysfunction (Idiopathic Pneumonia Syndrome) Following Allogeneic Stem Cell Transplantation.

ADVL0821: A Phase II Study of IMC-A12 (Anti-IGF-I Receptor Monoclonal Antibody, IND# 100947, NSC# 742460) in Children With Relapsed/Refractory Solid Tumors

ADVL04P2: A Feasibility Pilot and Phase 2 Study of Chemoimmunotherapy with Epratuzumab for Children with Relapsed CD22-Positive Acute Lymphoblastic Leukemia (ALL)

AAML0523: A Phase I/II Study of CLOLAR (Clofarabine IND# 73,789) in Combination with Cytarabine in Pediatric Patients with Refractory/Relapsed Leukemia

AALL07P1: A Phase II Pilot Trial of Bortezomib (PS-341, Velcade, IND# 58,443 ) in Combination with Intensive Re-Induction Therapy for Children with Relapsed Acute Lymphoblastic Leukemia (ALL) and Lymphoblastic Lymphoma (LL)

AAML07P1: A Phase II Pilot Study of Bortezomib (PS-341, Velcade, IND #58,443) Combined with Reinduction Chemotherapy in Children and Young Adults with Recurrent, Refractory or Secondary Acute Myeloid Leukemia